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Not all addictive drugs are associated with physical dependence, e.g., amphetamine, and not all drugs that produce physical dependence are addictive drugs, e.g., oxymetazoline

[181] A higher correlation with smoking has also been seen in people diagnosed with the major depressive disorder at any time throughout their lifetime compared to those without it

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Oxidative Stress-Induced Mitochondrial Dysfunction Drives Inflammation and Airway Smooth Muscle Remodeling in Patients With Chronic Obstructive Pulmonary Disease