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Tobacco smoking reduces p53, a tumor suppressor gene that is considered the genome guardian. Suppression of T-cell responses by Nicotine and tar is associated with decreased surveillance for tumor cells] reported that heavy smokers accumulate excess iron in hepatocytes which induces fibrosis and favors the development of HCC

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But the benefits [of smoking reduction] are only observed when it leads to permanent cessation, meaning quitting altogether, the authors add

In this new analysis, researchers linked data from the Coronary Artery Risk Development in Young Adults (CARDIA, 1995-2011) study to state, county and local smoke-free policies in restaurants, bars and workplaces

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