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Yes, but it's not completely neutral

Some people have had serious side effect while taking bupropion to help them quit smoking, including: New or worse mental health problems, such as changes in behavior or thinking, aggression, hostility, agitation, depression, or suicidal thoughts or actions

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A custome lothsome to the eye, hatefull to the Nose, harmefull to the braine, dangerous to the Lungs, and in the blacke stinking fume thereof, neerest resembling the horrible Stigian smoke of the pit that is bottomelesse A Counterblaste to Tobacco Written by King James I of England in 1604, A Counterblaste to Tobacco is one of the earliest diatribes against smoking