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Notably, the current literature remains asymmetric: kidney-to-lung mechanisms, particularly those involving circulating mtDAMPs and related inflammatory signaling, are supported by more concentrated evidence, whereas lung-to-kidney links are supported mainly by organ-level inflammatory, hypoxic, and hemodynamic mechanisms, with comparatively limited direct evidence linking pulmonary epithelial mitophagy to renal injury

27,28 Opioid manufacturers perfected techniques used by the tobacco industry on marketing their drugsthey sought out physicians through advertisements in medical professional publications and purposefully misled consumers about the addictive tendencies of their products

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