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However, with the exception of nicotine, most respondents were largely unaware of which constituents are present in cigarette smoke

Derebery J, Meltzer E, Nathan RA, Stang PE, Campbell UB, Corrao M, et al

In 2001, the Institute of Medicine issued a report faintly welcoming the creation of a safer cigarette as a feasible component of a harm-reduction strategy

In contrast, studies with lower scores (5) had limitations in selection representativeness, comparability, and follow-up adequacy, potentially introducing bias, particularly in those relying on self-reported COPD diagnosis rather than objective measures

Rae et al., 2001