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This inflammatory response has already been identified in seabirds leading to a condition which has been dubbed "plasticosis" and Marfella feels it is plausible that this could also be happening in humans

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Social isolation and lack of social support may mediate cancer disparities (425)Coughlin SS

Although this is one of the most detailed accounts of Twain's Nevada days (1861-4), it is deeply flawed by an over-reliance on Paine's biography, an acceptance of the fictionalized events in Roughing It as historical fact, and mixing rumors and legends into the narrative, gaining it Twain't status