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2 Smokeless tobacco contains 28 carcinogens, including the following: Nitrosamines The metabolites of tobacco-specific nitrosamines (NNK/NNN) are powerful carcinogens considered to be among the leading causes of oropharyngeal, oral cavity, and lung cancer for those who use tobacco products

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Rigorous assessments on the relationship of second-hand smoking to cancer and other diseases have been completed by the International Agency for Research on Cancer (IARC Working Group on the Evaluation of Carcinogenic Risk to Humans, 2004

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