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Reproductive Health Issues : Smoking can lead to complications during pregnancy, such as low birth weight and preterm birth, and can also affect fertility in both men and women

Trends Anal Chem 105:453469 Chowdhury P, Udupa KB (2006) Nicotine as a mitogenic stimulus for pancreatic acinar cell proliferation

Although cigarette butt litter has long been recognized as a major environmental cost associated with tobacco use, the available information about cigarette butt littering is limited to trash clean ups at specific locations and relatively few published studies

Its not just nicotine that goes into e-cigarettes

You had guys like Dale Earnhardt, Dale Earnhardt Jr, Alan Kulwicki, Carl Edwards, Matt Kenseth, Bobby,Terry Labonte and the list goes on forever