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PREPs were defined as products that substantially reduce exposure to one or more tobacco smoke toxicants as compared to exposures resulting from traditional tobacco products, and, that as a result, might be reasonably expected to reduce the risk of one or more specific diseases or other adverse health effects as compared to the risks associated with use of traditional tobacco products

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Under the ISO smoking regime, the yields of some toxicants were below the analysis reporting limit, but other than this there was a good deal of consistency in the directional changes across the three smoking regimes

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