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Though these effects of the spray are irritating, with regular use, they should lessen during the first week of therapy

This is a matter of significant public health concern due to the health risks associated with smoking and the potential for lifelong addiction

Veselska Z, Geckova A, Orosova O, Gajdosova B, van Dijk J, et al

Bertone-Johnson ER, Hankinson SE, Johnson SR, Manson JAE (2008) Cigarette smoking and the development of premenstrual syndrome

Researchers at the Wellcome Trust Sanger Institute, the Los Alamos National Laboratory, and their collaborators identified several different mechanisms by which tobacco smoking causes mutations in DNA