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Proverbs 23:20 NIV Do not join those who drink too much wine or gorge themselves on meat,

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Among them is cigarette smoking

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Consistently, in Gpr15 +/+ mice, prolonged cigarette smoke exposure in the TNBS model led to aggravated colitis, as reflected by greater weight loss, elevated DAI, colon shortening, and worsened histological and endoscopic scores, accompanied by increased Gpr15 expression (Supplementary Fig