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Competing interests: I have read and understood the BMJ policy on declaration of interests and declare the following interests: AJ receives consulting fees from DawnLight, Inc for work unrelated to this piece

Warnings about varenicline (Chantix) Varenicline carries a boxed warning regarding serious mental side effects that may occur while using the medicine, or immediately after stopping it

44 In addition, in BC xenograft mouse models, a reduction in tumor growth rate and metastasis, combined with decreased TAM infiltration, was observed when they were treated with macrophage-targeting chemotherapy (trabectedin) or CSF1 inhibitors, which highlighted a potential therapeutic opportunity

MR combines the results from different genetic studies to look for causal relationships between an exposure (in this case, smoking) and outcome (increased abdominal fat)

This is the case for the UK, at least - in countries with less regulation there may be other harmful chemicals added, like diacetyl, that are harmful to vape