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Cigarette smoking is the leading cause of preventable disease and death in the U.S., according to the Centers for Disease Control and Prevention, killing more than 480,000 people each year

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Carll et al

"Today's settlement with [parent company] Santa Fe Natural Tobacco Company ensures that all future advertisements make it clear that organic tobacco is no safer or healthier." The company has 30 days to update all advertising within 30 days to say "Organic tobacco does NOT mean safer cigarettes" and other similar statements about roll-your-own and pouch tobacco.

As mentioned above, it activates nicotinic acetylcholine receptors (nAChRs), triggering dopamine release in the mesolimbic system, a mechanism similar to other addictive drugs like heroin and cocaine