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Minimal inflammatory changes were noted in the subepithelial zone, along with parakeratosis (Fig

Further details regarding the chemical analyses are outlined in Supplementary Section S4, including HS-SPME-GCGC-TOFMS parameters (Supplementary Section S4.1) and SPME fibre selection (Supplementary Section S4.2)

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Although the aetiology is not clear, multiple factors that predispose to its onset are known, the most frequent being smoking and alcohol, tea and coffee consumption