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Before now, we had a large body of epidemiological evidence linking smoking with cancer, but now we can actually observe and quantify the molecular changes in the DNA due to cigarette smoking, explains Dr Ludmil Alexandrov, the first author from Los Alamos National Laboratory

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"I don't think the spirit of the law ever envisioned this type of cumbersome scrutiny." For example, Kessler said that under the FDA's guidelines, if the nation's third-biggest tobacco company wanted to take a Kent brand cigarette and rename it "Newport," it would be subject to review even though "it's not substantially equivalent it's exactly equivalent." Lorillard petitioned the agency in June seeking to speed the reviews

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