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It was revealed in the 1996 episode Musings of a Cigarette Smoking Man that the Smoking Man, a frustrated author raised in orphanages, assassinated JFK in the service of the government and framed Lee Harvey Oswald

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K., Othman, N., Choo, C

proposed standardization based on six criteria (duration of abstinence of 6 or 12 months, self-report of abstinence, biochemical verification, following up with protocol violators, collecting follow-up data blind to specific allocation groups, using intention-to-treat (ITT) approach in analysis) to define smoking abstinence and provide guidance for analysis and trial data reporting, to address this issue arising from such variation between trials [21]