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In a statement announcing the FDA actions, new Commissioner Robert Califf repeated the Campaign for Tobacco-Free Kids talking point that millions of youth are using these products and getting addicted to nicotine, and endorsed the FDA Center for Tobacco Products surprise 2021 decision to authorize only tobacco flavors unless manufacturers produce extraordinary evidence that flavored products will not attract youth use

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However, the authors also emphasize that these studies only amount to a level of limited evidence, and that [w]hether or not the levels of exposure are high enough to contribute to human carcinogenesis remains to be determined. Additionally, [t]here is no available evidence whether or not e-cigarette use is associated with intermediate cancer endpoints in humans, the report says

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