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One cigar needs a quick burn correction to stay on track, but other than that, the construction is good until I finish with each cigar

Int J Mol Sci 19:3084

Dimensions: 3619 x 2413 px | 30.6 x 20.4 cm | 12.1 x 8 inches | 300dpi Date taken: 27 June 2017 Photographer: STG/Jonas Gilles/REPORTERS/SCIENCE PHOTO LIBRARY

The interaction of AGEs with specific receptors, particularly the receptor for advanced glycation end-products (RAGE), triggers multiple intracellular signaling pathways, including NF-B, ERK1/2, p38, and MAPK, which in turn promote inflammatory responses and cellular stress (Yoshikawa et al., 2022