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Microglia and macrophages show altered activation thresholds, impaired debris clearance, and dysregulated cytokine production, changes that become increasingly pronounced in aging brain tissue (37)

The Taino (indigenous people of the Bahamas) observed how the Spanish men were curious and gave them tobacco leaves plus many other goods as welcoming gifts

3,4 Quitting smoking is notoriously difficult for many patients, and is caused, in large part, by the addictive properties of nicotine

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Occupational and Environmental Medicine