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Tobacco use kills more than 7 million people each year, and smoking tobacco is one of the most important risk factors for many lung diseases, as well as heart diseases and cancers

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GEE fits marginal generalised linear models by focusing on models for the mean of the correlated observations within clusters (without fully specifying the joint distribution of the observations) and is particularly suited to analysing clustered data, such as longitudinal data and repeated measures [60]

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