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We did not estimate RRs separately for different locations, sexes (although the RR of prostate cancer was estimated only for males and of cervical and breast cancer only for females) or age groups (although this analysis was applied to disease endpoints in adults aged 30 years only and, as detailed below, age-specific estimates were produced for the five CVD outcomes)

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Nicotine triggers the release of adrenaline (epinephrine), a hormone that prepares the body for a 'fight or flight' response