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The simplest form of these molecules is called phenol, whereas the term phenols refers to a class of similar molecules, of which seven are listed by the FDA as harmful or potentially harmful constituents of tobacco

In vitro experiments have shown that tobacco smoke extract activates the MAPK/AP-1 signaling pathway and promotes aberrant proliferation of urothelial cells 23 , while nicotine contributes to tumor progression and chemoresistance through activation of the PI3K/AKT/mTOR signaling axis 24

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Use among middle school-age children also increased nearly 50 percent