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They also reported smoking fewer cigarettes each week and weaker urges to smoke, on average, indicating lower levels of cigarette dependence

The FDA's January 2026 review of ZYN's modified-risk application included explicit consideration of youth exposure to reduced-risk messaging, with the agency noting that claim exposure did not increase use intentions among young adults but requiring ongoing post-market surveillance to detect unintended uptake [2]Source: Food and Drug Administration, "Meeting of the Tobacco Products Scientific Advisory Committee (TPSAC)", fda.gov

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Inflating the colon with air could cause a perforation, or hole, in the lining of the colon

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