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In recent studies, it has also been shown that tobacco has immunomodulatory effects by decreasing tumor necrosis factor-alfa and interleukin (IL)-1 levels that promote inflammation and increasing IL-6, IL-10, and transforming growth factor-beta levels that reduce inflammation

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[6] It was the work of Wolpe and Watson, which was based on Ivan Pavlov's work on learning and conditioning, that influenced Hans Eysenck and Arnold Lazarus to develop new behavioral therapy techniques based on classical conditioning

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