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As mentioned above, nicotine selectively activates nicotinic acetylcholine receptors (nAChRs), particularly those containing the 42 and 7 subunits, which in turn modulate dopamine, glutamate, serotonin, gamma-aminobutyric acid (GABA), and acetylcholine pathways associated with enhanced cognitive processing

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However, only a modest decline has occurred since 2010 and no change occurred between 2012 and 2013. Gwynn was diagnosed with cancer in 2010