Their cohort included 97,078 adults (33,138 men and 63,940 women) who resided in Ibaraki Prefecture and were aged 40-79 years at an annual health check-up in 1993
For reference, we also examined the effects of mainstream cigarette smoke (MCS), and to examine its contribution to e-cig toxicity, we studied the effects of acrolein, the aldehyde most implicated in the cardiovascular toxicity of smoking 21,31
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95% CI, 1.01-1.03) and secondhand smoke exposure in the past 7 days (aRR = 1.06 per 5 hours