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Developing tolerance and addiction: Use of psychoactive substances is associated with an increased risk of developing tolerance and addiction in vulnerable populations, as noted in the chapter THE NEUROBIOLOGY OF SUBSTANCE USE, MISUSE, AND ADDICTION from the 2016 publication by the Substance Abuse and Mental Health Services Administration (SAMHSA) , titled Facing Addiction in America: The Surgeon Generals Report on Alcohol, Drugs, and Health [Internet]