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A recent letter in JAMA Pediatrics found that among e-cigarette users, nearly 1.7 million high school students (about 1 in 3) and 425,000 middle school students (about 1 in 4) had used cannabis in e-cigarettes
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While the precise cellular and network mechanisms that underly nicotine induced seizures are not fully elucidated, the cholinergic nuclei in the brainstem and basal forebrain play key roles in arousal and attention via their effects on cortical tone and modulation of such systems could therefore theoretically affect the seizure threshold
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