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ovale are known for their ability to hibernate in the liver, which can give rise to relapses several weeks, months or even years after the patient is apparently cured

Types of Samples Cotinine can be measured in several biological specimens: Testing Methods Immunoassays (ELISA, rapid tests) Quick, inexpensive Can be qualitative (yes/no) or semi-quantitative Common in clinical and workplace screening Chromatography-based methods (GC-MS, LC-MS/MS) More accurate and quantitative Can distinguish nicotine from cotinine and other metabolites Used in research or forensic settings Interpretation of Results Cutoff values vary by lab and context

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