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390 The ALL-HEART trial, which included patients over the age of 60 with ischemic heart disease but without a history of gout, found that allopurinol did not reduce the incidence of non-fatal myocardial infarction, non-fatal stroke, or cardiovascular death over an average follow-up period of 4.8 years when compared to standard care

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Increased Skin Cell Turnover Nicotine causes blood vessels to constrict, limiting the supply of oxygen and antioxidants to skin cells