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The amount of cotinine detected also depends on the amount of exposure to nicotine: If you have smoked recently, a positive test may be 1,000 ng/mL

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The effects depend largely on the amount taken

Review on quantitation methods for hazardous pollutants released by e-cigarette (EC) smoking

It is also banned the use of tobacco residues resulting from smoking or tobacco on which any operations were performed that lead to the deterioration of its quality or characteristics during smoking