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Twenty-nine RCTs were selected from a systematic review conducted by Matkin et al.,251, 252, 253, 254, 255, 256, 257, 258, 259, 260, 261, 262, 263, 264, 265, 266, 267, 268, 269, 270, 271, 272, 273, 274, 275, 276, 277, 278, 279 and two more recent RCTs were added to reflect updated evidence.280, 281 Analysis of smoking cessation success rates at six months or longer showed that proactive telephone counseling by trained counselors significantly increased quit rates compared to the control interventions (RR, 1.30

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