The evidence suggests that cotinine concentration rises in a non-linear fashion with increasing number of cigarettes smoked, but the point where concentrations level off may vary across different populations
These differences complicate the ability to assess smoking-induced microbiome alterations and associated disease mechanisms in humans [140, 141]
However, these measures do not allow product comparability, as the dependence scores derived from each product-specific measure are not necessarily based on the same metric
But when they when they hit, they carry this weight
Additionally, if a previously taxed vapor product is repackaged, reconstituted, diluted or reprocessed, the tax does not apply to a subsequent sale of the vapor product