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[1] Unlike amphetamine abuse, where drug tolerance necessitates escalating doses to achieve the same effect, tolerance to clinically relevant doses of amphetamine plateaus after the initial titration period, and "drug holidays" (i.e., temporary treatment discontinuation) are not required to prevent the development of tolerance

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Additionally, they can modulate the redox state via histone deacetylase 1 (HDAC1)-dependent mechanisms, thereby attenuating oxidative damage in lung tissue (141, 142, 144)

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