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Introduction Harmful usage of tobacco ( Nicotiana spp.) is considered a public health problem of global concern, with 1.1 billion smokers worldwide ( Nicotiana rustica L., is associated with a strikingly different usage and repute ( Yuracar people, where korr-n-chata (i.e., healer) literally means he who eats tobacco ( Ashaninka ( Matsigenga ( sheripiari and seripigari , respectively) literally translate to the one intoxicated by tobacco. The Amazonian Keshwa people describe tobacco as the father of all plants ( Tobaccos historical migration from indigenous Latin America and its transformation from local medicinal plant to global substance of abuse ensued via its rapid popularization among Spaniards after the colonial arrival on the American continent: The plant was introduced to Europe in the late 15th century, where it was readily adopted, and an extensive chain of trade later stretching to Africa and Asia took its course ( Traditional medicines, defined as knowledge, skill and practices based on the theories, beliefs and experiences indigenous to different cultures, whether explicable or not, used in the maintenance of health, as well as in the prevention, diagnosis, improvement or treatment of physical and mental illnesses (p.8, WHO, 2019), play an increasingly central role in global modern healthcare, particularly for chronic conditions like cancer, diabetes, or chronic pain (WHO (2019) considers its inclusion to global primary healthcare as pivotal for achieving their declared goal of Universal Health Coverage and the Sustainable Development Goals ( Banisteriopsis caapi and varying admixture plants

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