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The decrease in IL-6 signaling that was predicted in the canonical pathway analysis done in IPA was supported by the in vitro experiments in which a decrease close to statistical significance was found ( p = 0.065) in EpiAirway tissues exposed to WS-23
Thereby difficulties associated with the identification of compounds from their corresponding derivatives, due to the absence of corresponding spectra in commercially available databases, and further complicated by the fact that some compounds may derivatize in more than one position, were avoided
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