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However, in a large number of studies on the potential impact of blood uric acid levels and the risk of hyperuricemia, smoking is usually considered a covariate, and the association between smoking and the occurrence of HUA is also still controversial in international clinical studies so far, and there is no consistent conclusion yet

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The global economic expenditure attributable to tobacco smoking, which includes both direct health expenditure and indirect costs from productivity loss, is estimated at $1.4 trillion per year, or 1.8% of global gross domestic product (GDP) 4,6

[134] As part of the Marshall Plan, the United States shipped free tobacco to Germany

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