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In studies of duloxetine in smoking and nonsmoking psychiatric patients (not directly related to pain relief), serum levels of the drug were lower in smokers than in nonsmokers, suggesting that tobacco smoke components induce drug-metabolizing enzymes (e.g., cytochrome P450 1A2) [108, 109]

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The company has spent 2.4 billion on creating the Iqos, which costs consists of a 45 battery pack that looks like a small mobile phone and charges a slim cigarette holder