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In addition to betel nut's carcinogenic properties, its hardness causes chronic friction against the inside of the cheek, which is also thought to contribute to cancer development

The chronic inflammation that is also present in COPD is exacerbated by the tobacco smoke carcinogen acrolein and its derivatives

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Proc Natl Acad Sci U S A (2004) 101(27):101438.10.1073/pnas.0401422101 30 KadaraHFujimotoJYooSYMakiYGowerACKabboutMet alTranscriptomic architecture of the adjacent airway field cancerization in non-small cell lung cancer