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- the used patch should be removed and a new one applied to a different skin site at the same time each day - if you have vivid dreams, you may removed the patch at bedtime and apply a new one in the morning - do not wear more than one patch at a time - do not cut patch in half or into smaller pieces - do not leave patch on for more than 24 hours because it may irritate your skin and loses strength after 24 hours - stop using the patch at the end of 8 weeks

The broader debate, about e-cigs' safety, will have even bigger implications for Pax and its many competitors

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Beyond the 14% of Americans smoking cigarettes, 3.8% are smoking cigars, 2.8% are using e-cigarettes or vaping, 2.1% use smokeless tobacco products, and 1% are using pipes

JAMA 2021;325(3):265279