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3.4 Limitations of stimuli-responsive nanoparticle designs Stimuli-responsive NP systems, including those triggered by pH, enzymatic activity, or ROS, depend on pathological thresholds that vary widely among patients, disease locations, and inflammatory states (Barros et al., 2026)

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Nambiar S, Tan D, Clynick B, Bong SH, Rawlinson C, Gummer J, et al

20 Prior to starting treatment for hypertriglyceridemia, reversible causes of hypertriglyceridemia, including medication effect (eg, exogenous estrogen or some diuretics) or some medical conditions (eg, hypothyroidism or excessive alcohol use) should be corrected if possible