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Other compounds targeting various mutant p53 proteins include PRIMA-1 and its methylated derivative APR-246, SCH29074 and CP-31398, which are thought to be able to restore WT TP53 function by promoting the proper folding of the mutant p53 protein [211,212,213]

Last year, the FDA proposed a rule that would prohibit the sale of menthol cigarettes and flavored cigars, and in October 2023, the FDA sent a final set of rules to the White House Office of Management and Budget for final review.[21] If imposed, the decrease in state and federal revenues would be substantial and likely fuel significantly higher levels of cigarette smuggling.[22] The first state to implement a statewide menthol flavor ban was Massachusetts

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