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Of note, most of the available evidence on toxicological profiles comes from industry funded studies (51, 59, 62), underscoring the need for independent, long term research to validate current findings and inform evidence-based regulatory decisions

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Protamines occur in two forms: protamine-1 (PRM1), found in all mammalian species, and protamine-2 (PRM2), only identified in a few species including humans, horses, mice, and hamsters

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