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TLR2, 4, and 9 displayed an 80% reduction in Ki-67 positivity, while TLR2 and 4 had a 65% reduction and TLR9 had a 35% reduction in ERG positivity ( Supplementary Figure S2 )

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In conclusion, men have a greater risk of developing moderate-to-severe and sight-threatening GO and should be carefully monitored and even more encouraged to regularly follow-up and stop smoking

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Indeed, the use of ASPs is no less harmful than conventional tobacco products