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Dedifferentiated RPE had globally decreased chromatin accessibility and expression of genes linked to hallmarks of aging. Notably, young, dedifferentiated RPE also exhibited a compensatory upregulation of hallmarks of aging-related genes including mitochondrial function and proteostasis while aged dedifferentiated RPE did not, which decreased their survival following CSC treatment, as experimentally verified with TUNEL labeling

Kleinstein SE, Nelson KE, Freire M