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3 Results 3.1 Epidemiology Recent national surveys among Italian adolescents aged 1315 years were prioritized in this review because they provide high-quality, nationally representative data within a well-defined regulatory framework, allowing for a clear interpretation of trends in youth tobacco and e-cigarette use ( Multiple factors contribute to the growing popularity of e-cigarettes among youth (Table 1)

Mast cells degranulate and produce bradykinin, which activates nociceptors

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Of those who had never smoked cigarettes, 1% were current e-cigarette users and 83% had never used e-cigarettes

Hanging around other smokers will make it more difficult to stop the habit